Histone Succinylation-Driven LINE-1 Reactivation Links High-Fat Diet Stress to Hepatic Inflammation and Liver Disease
Reem Daouk, Federico Cutrupi, Peng Liu, Arianna Mangiavacchi, Francesco Della Valle, Gabriele Morelli, Marco D'Onghia, Armin Niksic, Meritxell Huch, Valerio Orlando
This study shows high-fat diet stress reactivates LINE-1 elements via histone succinylation, causing inflammation and liver disease, and suggests L1 inhibition as a therapeutic approach.
bioRxiv · Dec 19, 2025 · PreprintMolecular Biology