Meritxell Huch

Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma

This study identifies altered epigenetic regulators and metabolic genes in cholangiocarcinoma, linking them to poor prognosis and metabolic-epigenetic crosstalk.

Protein arginine-methyltransferase 1 (PRMT1): a new pharmacological target in cholangiocarcinoma

This study identifies PRMT1 as a critical driver of cholangiocarcinoma growth and immune evasion, showing its inhibition enhances antitumor immunity and synergizes with immunotherapy.

A guide for establishing patient-derived organoids from bile samples obtained during endoscopic procedures and performing gene expression knockdown

This paper provides a protocol for generating bile-derived organoids from endoscopic samples and demonstrates gene expression knockdown in 3D cultures.

Histone Succinylation-Driven LINE-1 Reactivation Links High-Fat Diet Stress to Hepatic Inflammation and Liver Disease

This study shows high-fat diet stress reactivates LINE-1 elements via histone succinylation, causing inflammation and liver disease, and suggests L1 inhibition as a therapeutic approach.

Oxygen availability and hypoxia-independent action of HIF1α controls human trophoblast maturation and function

This study shows that oxygen levels and HIF1α act independently to regulate human trophoblast maturation and function in organoids.

The proportion of periportal mesenchyme to ductal epithelial cells acts as a proliferative rheostat in liver regeneration

This study shows that the ratio of periportal mesenchyme to ductal epithelial cells regulates ductal cell proliferation during liver regeneration through Notch signaling.

Lgr5+ stem/progenitor cells reside at the apex of the embryonic hepatoblast pool

The paper identifies Lgr5+ hepatoblasts as bi-potent liver progenitors that contribute to liver development and reside at the apex of the embryonic hepatoblast hierarchy.