GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner
Arnelle Löbbert, Nils Lorz, Edda S. F. Matthees, Philip Rößler, Carsten Hoffmann, Alvar D. Gossert
This study uses NMR to show GRK1 and GRK2 produce distinct phosphorylation patterns on C-terminal peptides of GPCRs, revealing time-dependent phosphorylation barcodes that may influence arrestin interactions during desensitization.
bioRxiv · May 6, 2025 · PreprintBiochemistry