Author

Edda S. F. Matthees

Jena University HospitalORCID 0000-0002-7760-5900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Carsten HoffmanniD· 2 shared Alvar D. GossertiD· 1 shared Arnelle Löbbert· 1 shared Carla Ziegler· 1 shared Julia DrubeiD· 1 shared Laura KlementiD· 1 shared Mona ReicheliD· 1 shared Nils LorziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Carsten HoffmannORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 6, 2025

GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner

Arnelle Löbbert, Nils Lorz, Edda S. F. Matthees…·Alvar D. Gossert

This study uses NMR to show GRK1 and GRK2 produce distinct phosphorylation patterns on C-terminal peptides of GPCRs, revealing time-dependent phosphorylation barcodes that may influence arrestin interactions during desensitization.

DOI 10.1101/2025.05.06.652336

proteomicsexperimental assay

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Pharmacology & ToxicologyJournal of Pharmacology and Experimental TherapeuticsPeer-reviewedMar 1, 2025

Relating GPCR domains with functionality: receptor helix-bundle and C-terminus differentially influence GRK-specific functions and β-arrestin-mediated regulation

Edda S. F. Matthees, Raphael Silvanus Haider, Laura Klement…·Carsten Hoffmann

The paper investigates how GPCR domains influence β-arrestin functions and conformational changes, revealing domain-specific effects on signaling outcomes.

3 citations

experimental assaycell signaling & trafficking

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