Loss of riboflavin biosynthesis leads to accumulation of select aromatic amino acids and loss of infectivity in Mycobacterium tuberculosis
Neetika Jaisinghani, Arshia Arasappan, Atul Pradhan, Rimanpreet Kaur, Kelin Li, Jeffrey Aubé, Justin R. Cross, Ruben J. Jesus Faustino Ramos, Travis E. Hartman, Mary Lou Previti, Charles Kyriakos Vorkas, Jessica C. Seeliger
This paper shows that disrupting riboflavin biosynthesis in Mycobacterium tuberculosis leads to metabolic changes and loss of infectivity in mice.
bioRxiv · Aug 5, 2026 · PreprintMicrobiology