Kelin Li

Dynamic view of an allosteric intermediate in a positively cooperative dimer

This paper stabilizes and analyzes the singly-bound intermediate of chorismate mutase to reveal that positive cooperativity arises from dynamic ensemble behavior rather than a simple two-state switch.

Loss of riboflavin biosynthesis leads to accumulation of select aromatic amino acids and loss of infectivity in Mycobacterium tuberculosis

This paper shows that disrupting riboflavin biosynthesis in Mycobacterium tuberculosis leads to metabolic changes and loss of infectivity in mice.

CD4+ Mucosal-associated Invariant T (MAIT) cells express highly diverse T cell receptors

This study identifies diverse TCR repertoires in CD4+ MAIT cells, showing they use non-TRAV1-2 TCRs and may recognize alternative MR1 ligands.

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.