Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits
Marta Pratelli, Anna M. Hakimi, Arth Thaker, Hui-quan Li, Swetha K. Godavarthi, Nicholas C. Spitzer
The paper shows that different drugs cause cognitive deficits by inducing glutamatergic neurons to adopt a GABAergic phenotype, which can be reversed by normalizing neuronal activity.
bioRxiv · Jun 16, 2022 · PreprintNeuroscience