Author

Hui-quan Li

University of California San DiegoORCID 0000-0001-9552-2191Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Nicholas C. SpitzeriD· 4 shared Marta PratelliiD· 3 shared Swetha K. GodavarthiiD· 3 shared Anna M. HakimiiD· 1 shared Arth Thaker· 1 shared Cong Chen· 1 shared Cynthia CzajkowskiiD· 1 shared Hollis T. ClineiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Nicholas C. SpitzerORCID

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4 papers

Recent·Most cited

Postsynaptic receptors regulate presynaptic neurotransmitter stability through trans-synaptic bridges

Swetha K. Godavarthi, Masaki Hiramoto, Yuri Ignatyev, Jacqueline B. Levin, Hui-quan Li, Marta Pratelli, Jennifer S. Borchardt, Cynthia Czajkowski, Laura N. Borodinsky, Lora B. Sweeney, Hollis T. Cline, Nicholas C. Spitzer

The paper shows that postsynaptic receptors influence presynaptic transmitter stability via trans-synaptic bridges, ensuring synaptic fidelity.

Proceedings of the National Academy of Sciences · Apr 3, 2024Peer-reviewedNeuroscience

Generalized fear following acute stress is caused by change in co-transmitter identity of serotonergic neurons

Hui-quan Li, Wuji Jiang, Lily Ling, Vaidehi Gupta, Cong Chen, Marta Pratelli, Swetha K. Godavarthi, Nicholas C. Spitzer

Acute stress causes generalized fear by switching serotonergic neuron co-transmitter from glutamate to GABA in mice, as observed in PTSD patients.

bioRxiv · May 10, 2023 · PreprintNeuroscience

Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits

Marta Pratelli, Anna M. Hakimi, Arth Thaker, Hui-quan Li, Swetha K. Godavarthi, Nicholas C. Spitzer

The paper shows that different drugs cause cognitive deficits by inducing glutamatergic neurons to adopt a GABAergic phenotype, which can be reversed by normalizing neuronal activity.

bioRxiv · Jun 16, 2022 · PreprintNeuroscience

Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain

Hui-quan Li, Nicholas C. Spitzer

The paper shows that one week of running in mice enhances motor skill learning by inducing neurotransmitter switching from ACh to GABA in specific neurons.

Nature Communications · May 4, 2020Peer-reviewedNeuroscience