Optimal compositions of potent sliced-siRNA with DNA bases substitution and insights of Ago2 slicing actions
Guihua Sun, Elizabeth M Lizhar, Yanhong Shi, Arthur D Riggs
The paper investigates sliDRNAs, DNA nucleotide-substituted sliced-siRNAs, to understand their processing, maturation, and silencing mechanisms compared to siRNA and insights into Ago2 slicing actions.
bioRxiv · Nov 5, 2026 · PreprintMolecular Biology