Yanhong Shi

The paper investigates sliDRNAs, DNA nucleotide-substituted sliced-siRNAs, to understand their processing, maturation, and silencing mechanisms compared to siRNA and insights into Ago2 slicing actions.

BRIDGE-AD integrates multimodal AD datasets to prioritize disease effectors, identifying 19 functional clusters and validating SCARB2 as a novel candidate.

This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.

The paper analyzes long-term cultured human islets to identify gene expression changes and cellular dynamics, revealing transdifferentiation and dedifferentiation processes.

This study uses temporal multi-modal single-cell profiling to show CAR-T cells interact dynamically with glioblastoma cells, including antigen-negative ones, and reduce their proliferation through IFN-gamma.