Viability of engineered AAVs via protein language models
Mélissa Desrosiers, Tommaso Ocari, Jeanne Trinquier, Emilia A. Zin, Timothé Van Meter, Maelle Delmas, Muge Tekinsoy, Arthur Planul, Takahiro Nemoto, Deniz Dalkara, Ulisse Ferrari
The paper uses AI to analyze the structural impact of 7-mer peptide insertions in AAV capsids, identifying viable modifications and their effects on capsid stability and function.
bioRxiv · Jun 11, 2026 · PreprintBioinformatics