Takahiro Nemoto

The paper uses AI to analyze the structural impact of 7-mer peptide insertions in AAV capsids, identifying viable modifications and their effects on capsid stability and function.

OddSNP predicts the success of multiplexed single-cell RNA-seq experiments using SNP-IC and cpSNP-IC metrics to optimize sequencing depth and donor complexity.

The paper determines the optimal sequencing depth for accurately measuring barcode concentrations in combinatorial genetic experiments by analyzing NGS data and incorporating a mathematical model of PCR amplification.

The paper introduces ACIDES, a method that improves performance estimation in directed evolution by combining statistical inference and in-silico simulations, tested on experimental and public datasets.