Mélissa Desrosiers

The paper uses AI to analyze the structural impact of 7-mer peptide insertions in AAV capsids, identifying viable modifications and their effects on capsid stability and function.

This study shows that expressing short-wavelength cone opsin in RGCs causes hyperpolarization, opposite to mid-wavelength opsin's depolarization, due to different G-protein activation.

The paper determines the optimal sequencing depth for accurately measuring barcode concentrations in combinatorial genetic experiments by analyzing NGS data and incorporating a mathematical model of PCR amplification.

The paper investigates why engineered AAV variants have lower titers and finds that DNAse digestion heat reduces their stability, leading to artificially low titers.

This study shows that optogenetic stimulation of AII amacrine cells restores both ON and OFF retinal responses and enables other retinal computations in degenerate retinas.

This study shows that Numb regulates Tau levels and prevents neurodegeneration in tauopathy models, with Numb-72 specifically reducing intracellular Tau.

The paper evaluates an optogenetic construct for vision restoration in non-human primates, demonstrating high temporal resolution and visual acuity above legal blindness.