Pharmacology & ToxicologybioRxivPreprint
CSF1R inhibitors pexidartinib and sotuletinib induce rapid glial ablation despite their limited brain penetrability
Olaf van Tellingen, Zoey J Tolboom, Yoran M Leter…·Laura E. Kuil
This study shows that high-dose CSF1R inhibitors pexidartinib and sotuletinib rapidly deplete microglia despite limited brain penetration, with significant off-target effects on other immune and tissue cells.
DOI 10.1101/2025.10.11.681780