Enterovirus A71 adaptation to heparan sulfate comes with capsid stability tradeoff
Han Kang Tee, Simon Crouzet, Arunima Muliyil, Gregory Mathez, Valeria Cagno, Matteo Dal Peraro, Aleksandar Antanasijevic, Sophie Clément, Caroline Tapparel
This study shows that EV-A71 adapts to heparan sulfate by losing pH-dependent uncoating, which compromises capsid stability and affects viral fitness in vivo.
eLife · Dec 23, 2024Peer-reviewedMicrobiology