Histidine exchange sustains LAT1 activity and proliferation in glutamine-addicted breast cancers.
Ersa Gjelaj, Paul C. Driscoll, Asad Mahmood, Josep Tarragó‐Celada, Michael Kossifos, Saidu Sesay, James I. MacRae, Mariia O. Yuneva
The paper identifies histidine as a key substrate for LAT1 that supports mTORC1 signaling and proliferation in glutamine-addicted breast cancers, revealing a metabolic vulnerability.
bioRxiv · Apr 19, 2026 · PreprintCancer Biology