Author

Paul C. Driscoll

The Francis Crick InstituteORCID 0000-0002-4124-6950Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

James I. MacRaeiD· 2 shared Ana Cunha· 1 shared Ananya BhallaiD· 1 shared Anita E. GrigoriadisiD· 1 shared Asad Mahmood· 1 shared Carin Andrea Brundin· 1 shared Cheryl GillettiD· 1 shared Dinis Pedro CaladoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

James I. MacRaeORCID

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2 papers

Recent·Most cited

Histidine exchange sustains LAT1 activity and proliferation in glutamine-addicted breast cancers.

Ersa Gjelaj, Paul C. Driscoll, Asad Mahmood, Josep Tarragó‐Celada, Michael Kossifos, Saidu Sesay, James I. MacRae, Mariia O. Yuneva

The paper identifies histidine as a key substrate for LAT1 that supports mTORC1 signaling and proliferation in glutamine-addicted breast cancers, revealing a metabolic vulnerability.

bioRxiv · Apr 19, 2026 · PreprintCancer Biology

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

Victoire Boulat, Elena Alberts, Paul C. Driscoll, Miu Shing Hung, Ana Cunha, Jelmar Quist, Fangfang Liu, Carin Andrea Brundin, Ananya Bhalla, Lidia Avalle, James Rosekilly, Lucy Ryan, Cheryl Gillett, Molly Strom, Valeria Poli, , Dinis Pedro Calado

This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.

bioRxiv · Aug 30, 2025 · PreprintCancer Biology