James I. MacRae

MEN1 deficiency establishes a selenite-dependent binary switch in ferroptosis

The paper shows MEN1 deficiency reduces ferroptosis by altering ACSL1 and GPX4 levels, with selenite affecting resistance.

Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

Histidine exchange sustains LAT1 activity and proliferation in glutamine-addicted breast cancers.

The paper identifies histidine as a key substrate for LAT1 that supports mTORC1 signaling and proliferation in glutamine-addicted breast cancers, revealing a metabolic vulnerability.

Natural statistics of host odours predict species-specific olfactory behaviours in Drosophilids

The paper shows that Drosophila species prefer odour components most distinctive in their natural host blends, revealing that olfactory behaviours exploit the statistical structure of odour environments.

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids

This study shows Mycobacterium tuberculosis remodels its lipidome to survive phosphate starvation by using phosphorus-free lipids and host-derived phosphate sources.

Integration of hunger and hormonal state gates infant-directed aggression

The paper shows how hunger and estrous state interact in the MPOA to regulate infant-directed aggression in mice.

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.

The essential host genome for Cryptosporidium intracellular survival exposes metabolic dependencies that can be leveraged for treatment

The paper uses a CRISPR-Cas9 screen to identify host genes critical for Cryptosporidium survival, revealing a metabolic dependency on host cholesterol biosynthesis that can be targeted for treatment.

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.

Horizontal gene transfer-initiated reorganization of lipid metabolism drives lifestyle innovation in a eukaryote

This study investigates how horizontal gene transfer of a squalene-hopene cyclase enables lipid metabolism rewiring in fission yeast, allowing adaptation to anoxic environments.

An intercellular metabolic relay for brain sparingin Drosophila

The paper identifies an intercellular metabolic relay involving glutamine and glutamate that sustains neural stem cell proliferation during brain sparing in Drosophila.

Bacterial whole-cell biosensors illuminate spatially variable sialic acid availability within the inflamed mammalian gut

The paper uses engineered bacterial biosensors to measure sialic acid availability in the inflamed mouse gut, revealing spatial and temporal variations linked to inflammation.

A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation

The paper introduces a chemical genetic system to map ZDHHC-specific S-acylation substrates at the whole proteome level in intact cells.

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

This study identifies transcriptional and chromatin changes during astrocyte maturation in vivo and in culture, showing that extrinsic signals regulate intrinsic transcription factors to drive maturation.

Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations

The paper shows Drosophila S2 cells exhibit daily gene and metabolic oscillations without canonical circadian regulators.

Phosphorylation of a Toxoplasma gondii tyrosine transporter by calcium-dependent kinase 3 is important for parasite fitness

This paper identifies a tyrosine transporter phosphorylated by TgCDPK3 in Toxoplasma gondii, showing its role in parasite fitness and metabolism beyond egress.