Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery
Maria Kano, 木村 妙子, Haruaki Yanagisawa, Komei Yamashita, Lisa Tatsumi, Asahi Sakai, Xinyi Li, Takaomi C. Saido, Takashi Saito, Sho Takatori, Masahide Kikkawa, Taisuke Tomita
The paper reports a cryo-EM structure of P301L/S320F double-mutant tau filaments induced in mice via peripheral AAV delivery, revealing a novel filament fold distinct from known tauopathies.
Acta Neuropathologica Communications · Aug 13, 2026Peer-reviewedNeuroscience