Taisuke Tomita

Aging disrupts tissue homeostasis and constrains blastema-mediated regeneration in the Cladonema medusa

This study shows that aging in Cladonema medusae impairs tissue homeostasis and blastema-mediated regeneration, highlighting shared constraints on regenerative systems across metazoans.

Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery

The paper reports a cryo-EM structure of P301L/S320F double-mutant tau filaments induced in mice via peripheral AAV delivery, revealing a novel filament fold distinct from known tauopathies.

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

Inhibition of NF-κB signaling pathway in astrocytes facilitates amyloid-β clearance by kallikrein-related peptidase 7

This study shows that inhibiting the NF-κB signaling pathway in astrocytes increases KLK7 expression and enhances amyloid-β clearance, suggesting a therapeutic target for Alzheimer's disease.

Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

This study identifies GPR34 as a regulator of microglial amyloid β fibril uptake, showing that its agonist enhances fibril clearance and that its expression declines with age and AD progression.

Aggregation of HAPLN2, a component of the perinodal extracellular matrix, is a hallmark of physiological brain aging in mice

This study identifies HAPLN2 aggregation as a feature of brain aging in mice, linking it to microglial activation and potential brain inflammation.

Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration

The paper reports cryo-EM structures of tau filaments formed in SH-SY5Y cells seeded with brain extracts from Alzheimer's and corticobasal degeneration cases, showing some structural templating.

Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy

Structures of α-synuclein filaments from multiple system atrophy

This study determines the structure of α-synuclein filaments in multiple system atrophy using cryo-EM, revealing distinct filament types and conformers that differ from in vitro assemblies.