Sho Takatori

This study shows that aging in Cladonema medusae impairs tissue homeostasis and blastema-mediated regeneration, highlighting shared constraints on regenerative systems across metazoans.

The paper reports a cryo-EM structure of P301L/S320F double-mutant tau filaments induced in mice via peripheral AAV delivery, revealing a novel filament fold distinct from known tauopathies.

This study shows that inhibiting the NF-κB signaling pathway in astrocytes increases KLK7 expression and enhances amyloid-β clearance, suggesting a therapeutic target for Alzheimer's disease.

This study identifies GPR34 as a regulator of microglial amyloid β fibril uptake, showing that its agonist enhances fibril clearance and that its expression declines with age and AD progression.

This study identifies HAPLN2 aggregation as a feature of brain aging in mice, linking it to microglial activation and potential brain inflammation.