Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
Collette A. LaVigne, Jaeil Han, He Zhang, Sihoon Cho, Min‐Seon Kim, Komal Sethia, Bret M. Evers, Asha Acharya, Tsung-Cheng Chang, Joshua T. Mendell
The paper identifies Plagl1 and Lrrc58 as trigger RNAs that induce degradation of miR-322-5p and miR-503-5p, leading to growth restriction in mice.
Genes & Development · Feb 1, 2026Peer-reviewedMolecular Biology