Joshua T. Mendell

The paper identifies Plagl1 and Lrrc58 as trigger RNAs that induce degradation of miR-322-5p and miR-503-5p, leading to growth restriction in mice.

The paper identifies EEF1G as a sensor of oxidative stress that modulates translation elongation to enhance selenoprotein production.

The paper identifies an ultraconserved snoRNA-like element in the lncRNA CRNDE that promotes ribosome biogenesis and cell proliferation in renal cell carcinoma.

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

This study shows that target-directed miRNA degradation (TDMD) regulates miRNA expression and embryonic growth in mammals by deleting Zswim8 and analyzing miRNA changes.

The paper shows that Kif1c mRNA localization to cell protrusions is required for directed cell migration and affects the specificity of KIF1C protein interactions.

This study identifies ZNF692 as a nucleolar scaffold that enhances 40S ribosome maturation and translation efficiency in rapidly proliferating cells, particularly in cancer cells.

This study shows that NORAD's interaction with PUMILIO, not RBMX, is essential for maintaining genomic stability in mammals.

This study shows that loss of the lncRNA Norad leads to PUMILIO hyperactivity, causing genomic instability and mitochondrial dysfunction, resulting in premature aging in mice.