Bret M. Evers

The paper investigates structural polymorphism in ATTR amyloid fibrils from a fourth patient, extending previous findings of two cardiac polymorphs to other organs.

The paper reports cryo-EM structures of cardiac AL amyloid fibrils from IGLV6 light chains, revealing conserved structural motifs and sequence-dependent folding mechanisms.

This study determines cryo-EM structures of brain-derived ATTR fibrils from patients with V30M and V30G variants, revealing distinct folds compared to peripheral tissues.

This study uses cryo-EM to reveal structural polymorphism in ex-vivo ALECT2 amyloid fibrils, identifying three morphologies and acetylation sites.

The paper identifies Plagl1 and Lrrc58 as trigger RNAs that induce degradation of miR-322-5p and miR-503-5p, leading to growth restriction in mice.

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

This study shows that the time of day affects cancer immunotherapy efficacy through a circadian clock-dependent chemokine axis in mice.

This study shows that airflow constraints can suppress tuberculosis transmission in guinea pigs, even under conditions that would otherwise allow transmission.

This study uses cryo-EM to analyze structural variability of apolipoprotein A-I amyloid fibrils across organs and mutations, revealing conformational differences and potential clinical implications.

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

This study shows that TMPRSS11B promotes an acidified and immunosuppressive tumor microenvironment in lung squamous cell carcinoma, suggesting it as a therapeutic target.

This study shows that a mutation in FicD causes diabetes by disrupting BiP AMPylation and pancreatic endocrine homeostasis in mice.

The paper uses cryo-EM to show that ATTR-T60A amyloid fibrils from multiple organs in patients have a consistent structural conformation.

The paper uses cryo-electron microscopy to characterize amyloid fibrils from the heart and liver of an ATTRv amyloidosis patient with the V122Δ mutation, finding structural polymorphism linked to polyneuropathy.

The paper detects seeding activity of tau assemblies in healthy human brains, suggesting normal physiological tau function that may contribute to disease when disrupted.

This study develops a method to maintain pig brain function under extracorporeal pulsatile circulatory control, preserving neural activity and hemodynamics.

This study shows that target-directed miRNA degradation (TDMD) regulates miRNA expression and embryonic growth in mammals by deleting Zswim8 and analyzing miRNA changes.

This study identifies a genetic variant in COL11A1 associated with adolescent idiopathic scoliosis and proposes a molecular model involving Pax1, Col11a1, and Mmp3 in spinal chondrocytes.

This study shows TP53 promotes neural lineage commitment in hESCs by regulating ciliogenesis and Shh signaling through BBS9.

This study shows that NHE6 inhibition corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load, suggesting a potential therapeutic strategy for Alzheimer's disease.

This study shows that STAG2-cohesin promotes myelination by generating promoter-anchored loops at myelination genes in oligodendrocytes, linking cohesin dysfunction to myelination defects in cohesinopathy.