Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network
Debabrata Jana, Priya Singh, Purnima Sailasree, Nithyapriya Kumar, Vijay V. Vishnu, Hanuman T Kale, Jyothi Lakshmi, Asha Kumari, Divya Tej Sowpati, P Chandra Shekar
This study shows mouse ESCs can efficiently self-organize into blastoids resembling mouse blastocysts through transient reactivation of the 2C gene network.
bioRxiv · Apr 12, 2023 · PreprintDevelopmental Biology