Author

Jyothi Lakshmi

Centre for Cellular and Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:machine learning (classical)· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ajaz Ahmad BhatiD· 2 shared Debabrata JanaiD· 2 shared Divya Tej SowpatiiD· 2 shared Hanuman T KaleiD· 2 shared Ikhlak AhmediD· 2 shared Khalid Adnan FakhroiD· 2 shared P Chandra ShekariD· 2 shared Priya SinghiD· 2 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Ajaz Ahmad BhatORCID

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Author profile →

4 papers

Recent·Most cited

DRB1 Subtyping Reveals Divergent Risk and Protection for Type 1 Diabetes in Middle Eastern Populations

Ikhlak Ahmed, William Hagopian, Muna Sunni, Hajar Dauleh, Hoda Azzam, Hamda A. Ali, Mohammad Bashir, Khalid Baggar, Dabia Mohanadi, Ajaz Ahmad Bhat, Jyothi Lakshmi, Shaima Salim, Evonne C. Chin-Smith, Sura Ahmed Hussain, Michael N. Weedon, , Ammira Al‐Shabeeb Akil

The paper develops a machine learning-based T1D risk model tailored to Middle Eastern populations, showing improved performance over existing models in this region.

medRxiv · Dec 2, 2025 · PreprintGenetic & Genomic Medicine

Improved Type 2 Diabetes Risk Stratification in the Qatar Biobank Cohort by Ensemble Learning Classifier Incorporating Multi-Trait, Population-Specific, Polygenic Risk Scores

Ikhlak Ahmed, Mubarak Ziab, Shahrad Taheri, Odette L. Chagoury, Sura Ahmed Hussain, Jyothi Lakshmi, Ajaz Ahmad Bhat, Khalid Adnan Fakhro, Ammira S. Al-Shabeeb Akil

The paper improves T2D risk prediction using ensemble learning with multi-trait polygenic risk scores in the Qatar Biobank cohort.

medRxiv · Jun 23, 2023 · PreprintGenetic & Genomic Medicine

Derivation of trophoblast stem cells unveils unrestrained potential of mouse ESCs and epiblast

Debabrata Jana, Purnima Sailasree, Priya Singh, Mansi Srivastava, Vijay V. Vishnu, Hanuman T Kale, Jyothi Lakshmi, G. Srinivas, Divya Tej Sowpati, P Chandra Shekar

This study derives trophoblast stem cells from mouse ESCs, showing they can contribute to the trophoectoderm and placenta, challenging the notion of restricted developmental potential.

bioRxiv · Apr 19, 2023 · PreprintDevelopmental Biology

Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network

Debabrata Jana, Priya Singh, Purnima Sailasree, Nithyapriya Kumar, Vijay V. Vishnu, Hanuman T Kale, Jyothi Lakshmi, Asha Kumari, Divya Tej Sowpati, P Chandra Shekar

This study shows mouse ESCs can efficiently self-organize into blastoids resembling mouse blastocysts through transient reactivation of the 2C gene network.

bioRxiv · Apr 12, 2023 · PreprintDevelopmental Biology