Divya Tej Sowpati

The paper catalogs mobile element insertions in 82 Indian populations, revealing population-specific variants not present in European databases and highlighting their potential impact on disease associations.

This study benchmarks nanopore-based DNA methylation detection tools across bacterial, plant, and mammalian datasets, finding older models best for CpG methylation and newer tools better for non-CG methylation.

This study identifies Rapgef1b's role in regulating Wnt/β-catenin signaling, affecting early embryonic tissue patterning, morphogenesis, and mitotic fidelity in zebrafish.

This study presents whole-genome and transcriptome analyses of breast tumors from India, identifying novel mutations, copy number alterations, and subtypes with clinical implications.

The paper presents a comprehensive genomic atlas of Indian populations, identifying novel variants and highlighting genetic diversity and pharmacogenomic implications.

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

ATaRVa improves TR genotyping accuracy and efficiency using long-read sequencing, excels in low coverage datasets, and includes motif decomposition and methylation profiling.

The paper analyzes whole-exome sequencing data from South Indian populations to identify founder events and deleterious mutations, revealing high inbreeding rates and population-specific pathogenic variants.

Ribbit identifies and annotates complex tandem repeat sequences in genomes with high accuracy and efficiency, outperforming existing tools in runtime and precision.

The paper develops improved models for detecting 6mA using Nanopore sequencing, achieving higher accuracy than existing methods.

The paper assembles and annotates the genome of Echis carinatus, identifying toxin-coding genes and providing a resource for venom research.

This study derives trophoblast stem cells from mouse ESCs, showing they can contribute to the trophoectoderm and placenta, challenging the notion of restricted developmental potential.

This study shows mouse ESCs can efficiently self-organize into blastoids resembling mouse blastocysts through transient reactivation of the 2C gene network.

The paper analyzes intra-host Single Nucleotide Variations (iSNVs) in SARS-CoV-2 genomes across multiple time points and regions, finding that many iSNVs later become population-level variants and some may contribute to immune escape.

DiviSSR uses a mathematical property of 2-bit DNA representations to quickly and accurately identify tandem repeats in genomic data.

This study identifies transcriptional changes in SARS-CoV-2 infected patients, showing upregulation of innate immunity and downregulation of sensory and neuro-related genes, linked to clinical symptoms.

The paper investigates how pericentromeric genome organization and chromatin factors regulate heterochromatic gene expression in Drosophila melanogaster using 5C-seq and RNAi experiments.

The paper analyzes SARS-CoV-2 genomes from India, identifying a distinct phylogenetic cluster (Clade I/A3i) that accounts for 41% of Indian isolates and 3.5% globally.

This paper presents a high-quality draft genome of Leptopilina boulardi, revealing its epigenetic features and developmental gene conservation, which supports further research on host-parasitoid interactions.

The paper presents the first draft genome assembly of an Asiatic lion and reports its genetic diversity, evolutionary history, and gene family expansions.

The paper analyzes the epigenomic and genomic features of heterochromatic genes in Drosophila melanogaster across developmental stages using modENCODE data, identifying distinct histone modification patterns and regulatory elements.

This study identifies and analyzes microsatellites across 719 eukaryotes, revealing evolutionary trends and species-specific patterns that reflect biological complexity.

C-State is a web app that enables interactive visualization and comparative analysis of epigenetic patterns across multiple genes and cell types.