Hanuman T Kale

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

The paper uses CRISPR-Cas9 screens to identify genes affecting stem cell fitness versus pluripotency identity, finding distinct and overlapping roles for chromatin and metabolic regulators.

Decoding Heterogenous Single-cell Perturbation Responses

The paper introduces a method to quantify diverse perturbation responses and discover novel biological insights in single-cell perturbation datasets.

Derivation of trophoblast stem cells unveils unrestrained potential of mouse ESCs and epiblast

This study derives trophoblast stem cells from mouse ESCs, showing they can contribute to the trophoectoderm and placenta, challenging the notion of restricted developmental potential.

Efficient self-organization of blastoids solely from mouse ESCs is facilitated by transient reactivation of 2C gene network

This study shows mouse ESCs can efficiently self-organize into blastoids resembling mouse blastocysts through transient reactivation of the 2C gene network.

TEX13B is important for germ cell development and male fertility

The paper investigates the role of TEX13B in male infertility by analyzing genetic variants and functional effects in germ cells.