Chronic exposure to PFAS triggers systems-level cellular reprogramming independent of their bioaccumulation
Jenise Z. Paddayuman, Judith R. Cristobal, Luane J. B. Landau, Ashleigh L. Gagnon, Ömer Gökçümen, Diana S. Aga, G. Ekin Atilla-Gokcumen
This study shows chronic PFAS exposure causes cellular reprogramming through oxidative stress and lipid metabolism changes, even with minimal accumulation.
bioRxiv · Jul 3, 2025 · PreprintPharmacology & Toxicology