Ömer Gökçümen

This study identifies rapid evolution of mouse saliva through regulatory rewiring and gene expansions, highlighting lineage-specific genes and sex-biased expression.

The paper reconstructs the evolutionary history of amylase duplications in primates, showing convergent expression patterns and functional divergence across species.

The paper identifies a rapid adaptive increase in AMY1 gene copy number in Indigenous Peruvian Andeans linked to potato domestication.

The paper analyzes segmental duplications in 117 vertebrate genomes and starfish, revealing species-specific patterns and rapid evolution of duplication landscapes.

This study identifies a CRIP3 non-synonymous variant associated with age-related hearing loss and provides genetic, functional, and evolutionary evidence for its role in auditory function.

The paper identifies spurious trans-QTLs caused by read mismapping from segmental duplications and estimates their prevalence in GTEx data.

This study investigates the evolution of saliva-related SCPP genes, identifying convergent duplications and positive selection in primates, with implications for adaptive diversification of saliva composition.

This study shows chronic PFAS exposure causes cellular reprogramming through oxidative stress and lipid metabolism changes, even with minimal accumulation.

The paper identifies switch-like genes across multiple tissues and links their expression patterns to disease susceptibility, finding tissue-specific and universally switch-like genes with potential therapeutic implications.

This study investigates the transcriptomic effects of six PFAS compounds on neuronal-like cells, identifying differentially expressed genes and metabolic changes associated with PFAS toxicity.

The paper analyzes ancient genomes from Northeast Brazil and compares them to other ancient and present-day data, revealing migration routes along South America's Atlantic coast and unexpected ancestry signals.

The paper identifies a candidate causal variant, rs77910749, that links enhanced cognitive performance with increased bipolar disorder risk through its effect on POU3F2 expression and amygdala function.

The paper identifies adaptive genomic structural variants across 26 populations using a network-based method and finds 577 variants with high population distribution, some overlapping with coding sequences or GWAS traits.

The paper identifies the origins of salivary proteins and reveals gene repertoires specific to fetal and adult salivary glands, showing functional diversity is driven by transcriptional regulators.

The paper identifies LoF-tolerant enhancers in the human genome, finding they are more tissue-specific and regulate fewer genes, with predictions supported by disease enhancers and sequencing data.

The paper identifies insertion sites of polymorphic duplications and finds a HERC2 haplotype under selection in European populations.

This study identifies 1,148 SV hotspots in the human genome, showing they are enriched for genes involved in critical functions and associated with medically relevant structural variations.

The paper investigates the evolutionary history of the GSTM1 gene deletion in East Asian populations, finding evidence of a soft sweep and its association with disease susceptibility.