Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic Efficacy
Stéfano M. Cirigliano, Richa Singhania, James Nicholson, Isha Monga, Yushan Wan, Caroline Haywood, Ashlesha Muley, Skylar A. Giacobetti, Howard Alan Fine
This study identifies drug-induced changes in glioblastoma stem cell states and shows that combining drugs targeting mesenchymal-like states improves anti-glioma activity.
bioRxiv · Sep 8, 2025 · PreprintCancer Biology