James Nicholson

Disruption of the Wnt-antagonist Apc in the pituitary stem cells drives the development of adamantinomatous craniopharyngioma.

This study shows that disrupting Apc in pituitary stem cells causes adamantinomatous craniopharyngioma (aCP) in mice, independent of β-catenin mutations, and identifies Sox2+ stem cells as the cell of origin.

Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic Efficacy

This study identifies drug-induced changes in glioblastoma stem cell states and shows that combining drugs targeting mesenchymal-like states improves anti-glioma activity.

Three-dimensional regulatory hubs support oncogenic programs in glioblastoma

This study identifies 3D regulatory hubs in glioblastoma stem cells and shows their role in oncogenic programs through computational and experimental analysis.

The inflammatory micro-environment induced by targeted CNS radiotherapy is underpinned by disruption of DNA methylation

This study shows that targeted CNS radiotherapy disrupts DNA methylation and induces neuroinflammation through epigenetic changes in brain tissue and cerebral organoids.