Oxygen carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia-induced suppression and improve cancer immunotherapy
Katarina Halpin-Veszeleiova, Michael P. Mallouh, Lucy M. Williamson, Ashley C Apro, Nuria Roxana Botticello-Romero, Camille Bahr, Maureen Shin, Kelly M. Ward, Laura Rosenberg, Vladimir B. Ritov, Michail V. Sitkovsky, Edwin Kerry Jackson, Bruce D. Spiess, Stephen Matthew Hatfield
This study shows oxygen-carrying nanoemulsions and respiratory hyperoxia reduce tumor hypoxia, enhance T cell and NK cell infiltration, and improve cancer immunotherapy outcomes.
JCI Insight · Mar 23, 2025Peer-reviewedImmunology