MyD88 deficiency modestly attenuates disease in a Leigh syndrome mouse model while enrofloxacin accelerates disease
Allison Rose Hanaford, Elizaveta A. Olkhova, Ryan W. Liao, Ashley Ching, Alvin Huang, Erin Shien Hsieh, Kino Watanabe, Yihan Chen, Megan Wichman, Noelle Hwang, Katerina James, Michael T. Mulholland, Vivian Truong, Holly Coulson, Kerry Gibbins, , Simon C. Johnson
The paper investigates the role of TLR signaling in Leigh syndrome using a mouse model and finds that MyD88 deficiency modestly improves disease outcomes, while enrofloxacin treatment accelerates disease progression.
Journal of Neuropathology & Experimental Neurology · Sep 4, 2026Peer-reviewedNeuroscience