Simon C. Johnson

The paper investigates the role of TLR signaling in Leigh syndrome using a mouse model and finds that MyD88 deficiency modestly improves disease outcomes, while enrofloxacin treatment accelerates disease progression.

This study investigates the effects of hypoxia and immune interventions in a mouse model of Leigh syndrome, showing that immune cell depletion suppresses disease and hypoxia cessation accelerates disease onset.