Author

Ernst‐Bernhard Kayser

Seattle Children's Research InstituteORCID 0000-0002-1632-8532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Allison Rose HanafordiD· 2 shared Anastasia Dimitriou· 2 shared Elizaveta A. OlkhovaiD· 2 shared Holly Coulson· 2 shared Katerina James· 2 shared Owen Cairns· 2 shared Simon C. JohnsoniD· 2 shared Vandana KaliaiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Allison Rose HanafordORCID

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2 papers

Recent·Most cited

MyD88 deficiency modestly attenuates disease in a Leigh syndrome mouse model while enrofloxacin accelerates disease

Allison Rose Hanaford, Elizaveta A. Olkhova, Ryan W. Liao, Ashley Ching, Alvin Huang, Erin Shien Hsieh, Kino Watanabe, Yihan Chen, Megan Wichman, Noelle Hwang, Katerina James, Michael T. Mulholland, Vivian Truong, Holly Coulson, Kerry Gibbins, , Simon C. Johnson

The paper investigates the role of TLR signaling in Leigh syndrome using a mouse model and finds that MyD88 deficiency modestly improves disease outcomes, while enrofloxacin treatment accelerates disease progression.

Journal of Neuropathology & Experimental Neurology · Sep 4, 2026Peer-reviewedNeuroscience

Hypoxia versus immune depletion - immune profiling and treatment cessation provide mechanistic insights and considerations for translation in Leigh syndrome

Elizaveta A. Olkhova, Ernst‐Bernhard Kayser, Anastasia Dimitriou, Mulholland Michael, Holly Coulson, Vivian Truong, Owen Cairns, Katerina James, Johnson M Brittany, Monika Winter, Vandana Kalia, Surojit Sarkar, Allison Rose Hanaford, Simon C. Johnson

This study investigates the effects of hypoxia and immune interventions in a mouse model of Leigh syndrome, showing that immune cell depletion suppresses disease and hypoxia cessation accelerates disease onset.

bioRxiv · Aug 19, 2026 · PreprintPathology