NLRX1 is an essential, druggable regulator of mitochondrial permeability transition
Rachel E. Heap, David W. Frederick, Robert J. Pickering, Sonja Ghidelli‐Disse, Kirsten L. Searle, Juliette C. Barber, Nicholas W. Galwey, Léa P. Wilhelm, Kathy Triantafilou, Martha Triantafilou, O. P. Wright, Sumitra Ramachandran, Yan-Ming Tan, Wenhao Xia, Chiu-Cheong Aw, , Lee M. Booty
This study identifies NLRX1 as a druggable, CypD-independent regulator of mitochondrial permeability transition using chemical probes and genetic approaches.
bioRxiv · Aug 26, 2026 · PreprintCell Biology