Léa P. Wilhelm

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

This study identifies NLRX1 as a druggable, CypD-independent regulator of mitochondrial permeability transition using chemical probes and genetic approaches.

The paper identifies a new mechanism of kinase inhibition through electrophilic modifications, revealing aspartate conjugation of ULK1 by a chloroacetamide warhead.