Lee M. Booty

NLRX1 is an essential, druggable regulator of mitochondrial permeability transition

This study identifies NLRX1 as a druggable, CypD-independent regulator of mitochondrial permeability transition using chemical probes and genetic approaches.

Plate-based ISD-SPE enables dual proteome-secretome concentration-response profiling of TLR signalling in iPSC-derived macrophages

This paper introduces a plate-based ISD-SPE workflow for integrated proteome and secretome analysis of TLR signaling in macrophages, showing improved reproducibility and scalability for drug discovery.

dia-PASEF Enables Rapid Profiling of the Human Secretome for Deeper Insights into Cellular Dynamics and Inflammatory Mechanisms

The paper introduces dia-PASEF, a mass spectrometry workflow for rapid secretome profiling, revealing novel inflammatory responses and dynamic secretion patterns in macrophages.

MALDI-TOF mass spectrometry and proteomics as phenotypic screening tools for anti-inflammatory drugs

This study evaluates two mass spectrometry-based phenotypic screening approaches for identifying anti-inflammatory compounds in macrophages and compares them to cytokine profiling.

Pulmonary macrophage subsets display distinct metabolic responses to polarising stimuli in vivo

This study investigates how pulmonary macrophage subsets respond metabolically to polarizing stimuli in vivo, revealing distinct metabolic profiles between alveolar and interstitial macrophages.