Rachel E. Heap

NLRX1 is an essential, druggable regulator of mitochondrial permeability transition

This study identifies NLRX1 as a druggable, CypD-independent regulator of mitochondrial permeability transition using chemical probes and genetic approaches.

Plate-based ISD-SPE enables dual proteome-secretome concentration-response profiling of TLR signalling in iPSC-derived macrophages

This paper introduces a plate-based ISD-SPE workflow for integrated proteome and secretome analysis of TLR signaling in macrophages, showing improved reproducibility and scalability for drug discovery.

dia-PASEF Enables Rapid Profiling of the Human Secretome for Deeper Insights into Cellular Dynamics and Inflammatory Mechanisms

The paper introduces dia-PASEF, a mass spectrometry workflow for rapid secretome profiling, revealing novel inflammatory responses and dynamic secretion patterns in macrophages.

MALDI-TOF mass spectrometry and proteomics as phenotypic screening tools for anti-inflammatory drugs

This study evaluates two mass spectrometry-based phenotypic screening approaches for identifying anti-inflammatory compounds in macrophages and compares them to cytokine profiling.