SUV39H1 mediated regulation of KLF4 and KDM4A coordinate smooth muscle cell phenotypic plasticity
Payel Chatterjee, Raja Chakraborty, Ashley J. Sizer, Brendan O'Brien, Peng Xu, Jonathan M. Hwa, Yi Xie, Qin Yan, John Hwa, Kathleen A. Martin
This study identifies SUV39H1 as an epigenetic regulator promoting VSMC dedifferentiation by stabilizing KLF4 and altering chromatin state during phenotypic plasticity.
Arteriosclerosis Thrombosis and Vascular Biology · Aug 21, 2025Peer-reviewedCell Biology