Qin Yan

This paper introduces FastBindRank, a distillation-based framework for high-fidelity virtual screening of large chemical libraries, achieving higher hit rates and discovery yields than traditional methods.

This study demonstrates that MET-targeting VHH-CAR-T cells effectively kill tumor cells in vitro and control tumor growth in vivo.

This study shows lysine lactylation at stress-response gene TSSs is enriched under glucose starvation in canine hemangiosarcoma and correlates with transcriptional activation.

The paper identifies KDM2A as a key regulator of metastatic competence in tumor cell clusters through epigenetic modulation of oxidative phosphorylation and cell junction integrity.

This study identifies SUV39H1 as an epigenetic regulator promoting VSMC dedifferentiation by stabilizing KLF4 and altering chromatin state during phenotypic plasticity.

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.