Kathleen A. Martin

SUV39H1 mediated regulation of KLF4 and KDM4A coordinate smooth muscle cell phenotypic plasticity

This study identifies SUV39H1 as an epigenetic regulator promoting VSMC dedifferentiation by stabilizing KLF4 and altering chromatin state during phenotypic plasticity.

Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane

This study shows emerin, a nuclear envelope protein, is expressed in red blood cells and regulates membrane structure and function, with mutations linked to RBC phenotypes like MCV.

Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability

This study identifies PRC2 as a driver of atherosclerosis by suppressing Klf2/4, and shows that inhibiting PRC2 with tazemetostat reduces plaque progression and improves stability.

Epigenetic Remodeling in Human Coronary Artery Smooth Muscle Cell Phenotypic Switching

The paper identifies novel regulatory elements and chromatin changes in human coronary artery smooth muscle cells during phenotypic switching, linking them to cardiovascular disease-associated SNPs and signaling pathways.

Angiogenic Signaling Counteracts Shear Stress-driven Arterial Patterning.

This study shows VEGF inhibits arterial specification in capillaries by suppressing Sox17, preventing premature arterialization driven by shear stress.

TCF7L2 Regulation of GATA6-dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia

This study shows TCF7L2 promotes VSMC differentiation and inhibits proliferation, reducing intimal hyperplasia in mice with LRP6 mutations.