Author

Raja Chakraborty

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Kathleen A. MartiniD· 4 shared Divyesh JoshiiD· 2 shared Martin Alexander SchwartziD· 2 shared Anna TuliakovaiD· 1 shared Anthony Wayne OrriD· 1 shared Ashley J. Sizer· 1 shared Boris Ν. KholodenkoiD· 1 shared Brendan O'BrieniD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

Kathleen A. MartinORCID

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4 papers

Recent·Most cited

SUV39H1 mediated regulation of KLF4 and KDM4A coordinate smooth muscle cell phenotypic plasticity

Payel Chatterjee, Raja Chakraborty, Ashley J. Sizer, Brendan O'Brien, Peng Xu, Jonathan M. Hwa, Yi Xie, Qin Yan, John Hwa, Kathleen A. Martin

This study identifies SUV39H1 as an epigenetic regulator promoting VSMC dedifferentiation by stabilizing KLF4 and altering chromatin state during phenotypic plasticity.

Arteriosclerosis Thrombosis and Vascular Biology · Aug 21, 2025Peer-reviewedCell Biology

Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability

Divyesh Joshi, Raja Chakraborty, Tejas Bhogale, Jessica Furtado, Hanqiang Deng, James G. Traylor, Anthony Wayne Orr, Kathleen A. Martin, Martin Alexander Schwartz

This study identifies PRC2 as a driver of atherosclerosis by suppressing Klf2/4, and shows that inhibiting PRC2 with tazemetostat reduces plaque progression and improves stability.

bioRxiv · Dec 2, 2024 · PreprintCell Biology

Epigenetic Remodeling in Human Coronary Artery Smooth Muscle Cell Phenotypic Switching

Raja Chakraborty, Vincent Schulz, Kimberly Lezon-Geyda, Jui M. Dave, Kathleen A. Martin, Patrick G. Gallagher

The paper identifies novel regulatory elements and chromatin changes in human coronary artery smooth muscle cells during phenotypic switching, linking them to cardiovascular disease-associated SNPs and signaling pathways.

bioRxiv · Apr 11, 2024 · PreprintGenomics

Angiogenic Signaling Counteracts Shear Stress-driven Arterial Patterning.

Dongying Chen, Oleksii S. Rukhlenko, Divyesh Joshi, Martina Rudnicki, Brian G. Coon, Raja Chakraborty, Anna Tuliakova, Elena Ioannou, Kathleen A. Martin, Boris Ν. Kholodenko, Christiana Ruhrberg, Martin Alexander Schwartz, Michael Simons

This study shows VEGF inhibits arterial specification in capillaries by suppressing Sox17, preventing premature arterialization driven by shear stress.

bioRxiv · Jan 23, 2024 · PreprintDevelopmental Biology