TDP-43 oligomers detected as initial intermediate species during aggregate formation
Rachel L. French, Ashley N. Reeb, Himani Aligireddy, Niraja Kedia, Dhruva D. Dhavale, Zachary R. Grese, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala
This study identifies TDP-43 oligomers as early intermediates in aggregation, showing ALS-linked mutations accelerate this process and enhance aggregate propagation.
bioRxiv · Dec 17, 2018 · PreprintBiochemistry