Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines
Amin Addetia, Alexandra Schäfer, Kaitlin R. Sprouse, Adian Valdez, Ashley Taylor, Mary-Jane Navarro, Jack T Brown, Elizabeth M. Leaf, Marcos C. Miranda, Alexandra C. Walls, Jimin Lee, Nicholas Catanzaro, Catherine Treichel, Isabelle Willoughby, John Powers, , David Veesler
This paper designs multivalent RBD nanoparticle vaccines that overcome immune imprinting and provide broad protection against SARS-CoV-2 variants and sarbecoviruses.
bioRxiv · May 11, 2025 · PreprintImmunology