Jack T Brown

Computational design of potent, broadly neutralizing anti-Nipah virus and Hendra virus miniproteins

This paper computationally designs thermostable miniproteins that neutralize Nipah and Hendra viruses with subnanomolar affinity and potent in vitro antiviral activity.

Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans

The paper shows repeated SARS-CoV-2 vaccine boosters elicit variant-specific memory B cells and neutralizing antibodies, suggesting immune imprinting can be overcome with updated vaccines.

A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variants

This paper describes a miniprotein inhibitor that neutralizes multiple SARS-CoV-2 variants and protects mice against them when administered post-exposure.

Designed miniproteins potently inhibit and protect against MERS-CoV

This study designs miniproteins that inhibit MERS-CoV by targeting the spike protein, showing broad neutralization and protective efficacy in mice.

Potent neutralization of Marburg virus by a vaccine-elicited monoclonal antibody

This study identifies a potent monoclonal antibody, MARV16, that broadly neutralizes Marburg virus and related viruses, with a cryo-EM structure revealing its mechanism of action.

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines

This paper designs multivalent RBD nanoparticle vaccines that overcome immune imprinting and provide broad protection against SARS-CoV-2 variants and sarbecoviruses.

SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals

This study shows SARS-CoV-2 nsp1 inhibits translation in bat cells and human cells, revealing its broad activity across mammals.

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

HKU5 merbecoviruses use bat Pipistrellus abramus ACE2 and several artiodactyl ACE2s through a cryo-EM-defined binding mode distinct from other ACE2-using coronaviruses, showing independent evolution of ACE2 usage.

Molecular basis of pathogenicity of the recently emerged FCoV-23 coronavirus

This study identifies molecular mechanisms of FCoV-23 pathogenicity, including receptor usage and biotype switching, and identifies a cross-reactive antibody for therapeutic development.