Mannosylated nanoparticle immunogens enhance the circumsporozoite protein-specific B cell response and improve protection against sporozoite challenge
Courtney E McDougal, Mark D. Langowski, Daria Nikolaeva, Chengbo Chen, Derek J. Bangs, Adian Valdez, Rashmi Ravichandran, Suna Cheng, Mariah Lofgren, Marlon Dillon, Delante Sanders, Alvaro Molina-Cruz, Azza H. Idris, Kazutoyo Miura, Kelly Lee, , Neil P. King
This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.
bioRxiv · May 7, 2026 · PreprintImmunology