PACS1 syndrome variant alters proteomic landscape of developing cortical organoids
Ximena Gómez-Maqueo, Lauren E. Rylaarsdam, Ashley Woo, Annika L. Schroder, Jennifer Rakotomamonjy, Clare L Bossert, Tess A Smith, Shelby Ruiz, Jordan Gilardi, Lambertus Klei, Bernie Devlin, Matthew L. MacDonald, Alicia Guemez‐Gamboa
This study examines how the PACS1 p.R203W variant affects the proteomic landscape of brain organoids, identifying dysregulated proteins and processes linked to neurodevelopmental disorders.
bioRxiv · Apr 23, 2025 · PreprintNeuroscience