Conditional upregulation of KCC2 selectively enhances neuronal inhibition during seizures
Chelsea S. Goulton, Miho Watanabe, Dennis Lawrence Cheung, KW Wang, T Oba, Ashor Khoshaba, D. Lai, Hitoshi Inada, K Eto, Kayo Nakamura, John Power, TM Lewis, Gary D. Housley, Hiroaki Wake, Junichi Nabekura, Andrew John Moorhouse
This study shows that increasing KCC2 in mice reduces seizure-like activity and prevents status epilepticus, suggesting KCC2 targeting could help treat excitation-inhibition imbalances.
bioRxiv · Jan 30, 2018 · PreprintNeuroscience